Projects in this subgroup combine structure, function, and simulation approaches to characterize various types of pentameric ligand-gated ion channels, particularly their modulation by allosteric drugs such as alcohol, anesthetics, or insecticides.
Contributors:
Reba Howard, Team Lead- Erik Lindahl, Professor
- Chen Fan, Researcher
- John Cowgill, Postdoc
- Nandan Haloi, Postdoc
- Farzaneh Jalalypour, Postdoc
- Olivia Andén, PhD Student
- Cathrine Bergh, PhD Student
- Anton Jansen, PhD Student
- Emelia Karlsson, PhD Student
- Urška Rovšnik, PhD Student
- Tatjana Shugaeva, PhD Student
- Yuxuan Zhuang, PhD Student
Recent publications
- Lycksell M, Rovšnik U, Hanke A, Martel A, Howard RJ, Lindahl E. Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel (2022) Proceedings of the National Academy of Sciences of the USA 119(50): e2210669119. doi: 10.1073/pnas.2210669119
- Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E. Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators (2022) Proceedings of the National Academy of Sciences of the USA 119(43): e2208081119. doi: 10.1073/pnas.2208081119
- Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE. Structural and dynamic mechanisms of GABA(A) receptor modulators with opposing activities (2022) Nature Communications 13: 4582. doi: 10.1038/s41467-022-32212-4
- Bergh C, Heusser SA, Howard RJ, Lindahl E. Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel (2021) eLife 10: e68369. doi: 10.7554/eLife.68369
- Lycksell M, Rovšnik U, Bergh C, Johansen NT, Martel A, Porcar L, Arleth L, Howard RJ, Lindahl E. Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering (2021) Proceedings of the National Academy of Sciences of the USA 118(37): e2108006118. doi: 10.1073/pnas.2108006118
- Howard RJ. Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models (2021) Journal of Molecular Biology 433(17): 167128. doi: 10.1016/j.jmb.2021.167128
- Rovšnik U, Zhuang Y, Forsberg BO, Carroni M, Yvonnesdotter L, Howard RJ, Lindahl E. Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations (2021) Life Science Alliance 4(8): e202101011. doi: 10.26508/lsa.202101011
- Sridhar A*, Lummis SCR*, Pasini D, Mehregan A, Brams M, Kambara K, Bertrand D, Lindahl E, Howard RJ, Ulens C. Regulation of a pentameric ligand-gated ion channel by a semi-conserved cationic-lipid binding site (2021) Journal of Biological Chemistry 297(2): 100899. doi: 10.1016/j.jbc.2021.100899
- Hu H, Howard RJ, Bastolla U, Lindahl E, Delarue M. Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel (2020) Proceedings of the National Academy of Sciences of the USA 117(24): 13437–13446. doi: 10.1073/pnas.1922701117
- Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. Shared structural mechanisms of general anaesthetics and benzodiazepines (2020) Nature 585: 303–308. doi: 10.1038/s41586-020-2654-5
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