Projects in this subgroup combine structure, function, and simulation approaches to characterize various types of pentameric ligand-gated ion channels, particularly their modulation by allosteric drugs such as alcohol, anesthetics, or insecticides.
Contributors:
Reba Howard, Team Lead- Erik Lindahl, Professor
- Paul Bauer, Researcher
- Artem Zhmurov, Researcher
- Linnea Axelsson, PhD Student
- Cathrine Bergh, PhD Student
- Marie Lycksell, PhD Student
- Urška Rovšnik, PhD Student
- Yuxuan Zhuang, PhD Student
Recent publications
- Hu H, Howard RJ, Bastolla U, Lindahl E, Delarue M. Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the USA (2020) 117(24): 13437–13446. doi: 10.1073/pnas.1922701117
- Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE. Agonist selectivity and ion permeation in the α3β4 ganglionic nicotinic receptor. Neuron (2019) 104(3): 501–511.e6. doi: 10.1016/j.neuron.2019.07.030
- Heusser SA, Lycksell M, Wang X, McComas SE, Howard RJ, Lindahl E. Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity. Proceedings of the National Academy of Sciences of the USA (2018) 115(42): 10672–10677. doi: 10.1073/pnas.1809650115