Projects in this team combine structural, functional, and computational approaches to characterize complex biomolecules. Members are engaged at various levels in connecting insights between experimental biochemistry data and molecular dynamics simulations. Historically, the team has focused on applications to the rich allostery and pharmaceutical potential of ligand-gated ion channels.
Contributors:
Reba Howard, Team Lead- Erik Lindahl, Professor
- Cathrine Bergh, Researcher
- John Cowgill, Researcher
- Chen Fan, Researcher
- Nandan Haloi, Researcher
- Farzaneh Jalalypour, Researcher
- Olivia Andén, PhD Student
- Anton Jansen, PhD Student
- Emelia Karlsson, PhD Student
- Samuel Eriksson Lidbrink, PhD Student
- Urška Rovšnik, PhD Student
- Tatjana Shugaeva, PhD Student
- Yuxuan Zhuang, PhD Student
Recent publications
- Cowgill J*, Fan C*, Haloi N, Tobiasson V, Zhuang Y, Howard RJ°, Lindahl E° (2023) Structure and dynamics of differential ligand binding in the human ρ-type GABA(A) receptor. Neuron (online now). doi: 10.1016/j.neuron.2023.08.006
- Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E°, Hibbs RE° (2023) Structural insights into opposing actions of neurosteroids on GABA(A) receptors. Nature Communications 14: 5091. doi: 10.1038/s41467-023-40800-1
- Lycksell M*, Rovšnik U*, Hanke A, Martel A, Howard RJ, Lindahl E (2022) Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the USA 119(50): e2210669119. doi: 10.1073/pnas.2210669119
- Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E (2022) Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators. Proceedings of the National Academy of Sciences of the USA 119(43): e2208081119. doi: 10.1073/pnas.2208081119
- Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE (2022) Structural and dynamic mechanisms of GABA(A) receptor modulators with opposing activities. Nature Communications 13: 4582. doi: 10.1038/s41467-022-32212-4
- Bergh C, Heusser SA, Howard RJ, Lindahl E (2021) Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel. eLife 10: e68369. doi: 10.7554/eLife.68369
- Howard RJ (2021) Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models. Journal of Molecular Biology 433(17): 167128. doi: 10.1016/j.jmb.2021.167128
*Equal contributions; °Co-corresponding authors
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