Projects in this subgroup combine structure, function, and simulation approaches to characterize various types of pentameric ligand-gated ion channels, particularly their modulation by allosteric drugs such as alcohol, anesthetics, or insecticides.
Contributors:
Reba Howard, Team Lead- Erik Lindahl, Professor
- Paul Bauer, Researcher
- Akshay Sridhar, Postdoc
- Olivia Andén, PhD Student
- Cathrine Bergh, PhD Student
- Anton Jansen, PhD Student
- Marie Lycksell, PhD Student
- Urška Rovšnik, PhD Student
- Linnea Yvonnesdotter, PhD Student
- Yuxuan Zhuang, PhD Student
Recent publications
- Rovšnik U, Zhuang Y, Forsberg BO, Carroni M, Yvonnesdotter L, Howard RJ, Lindahl E. Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations. Life Science Alliance (in press). doi: 10.26508/lsa.202101011
- Sridhar A*, Lummis SCR*, Pasini D, Mehregan A, Brams M, Kambara K, Bertrand D, Lindahl E, Howard RJ, Ulens C. Regulation of a pentameric ligand-gated ion channel by a semi-conserved cationic-lipid binding site. Journal of Biological Chemistry (in press). doi: 10.1016/j.jbc.2021.100899
- Hu H, Howard RJ, Bastolla U, Lindahl E, Delarue M. Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the USA (2020) 117(24): 13437–13446. doi: 10.1073/pnas.1922701117
- Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature (2020) 585: 303–308. doi: 10.1038/s41586-020-2654-5
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