Projects in this subgroup combine structure, function, and simulation approaches to characterize various types of pentameric ligand-gated ion channels, particularly their modulation by allosteric drugs such as alcohol, anesthetics, or insecticides.
Contributors:
Reba Howard, Team Lead- Erik Lindahl, Professor
- Paul Bauer, Researcher
- Chen Fan, Researcher
- John Cowgill, Postdoc
- Nandan Haloi, Postdoc
- Farzaneh Jalalypour, Postdoc
- Akshay Sridhar, Postdoc
- Olivia Andén, PhD Student
- Cathrine Bergh, PhD Student
- Anton Jansen, PhD Student
- Marie Lycksell, PhD Student
- Urška Rovšnik, PhD Student
- Linnea Yvonnesdotter, PhD Student
- Yuxuan Zhuang, PhD Student
Recent publications
- Bergh C, Heusser SA, Howard RJ, Lindahl E. Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel. eLife 10: e68369. doi: 10.7554/eLife.68369
- Lycksell M, Rovšnik U, Bergh C, Johansen NT, Martel A, Porcar L, Arleth L, Howard RJ, Lindahl E. Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering. Proceedings of the National Academy of Sciences of the USA 118(37): e2108006118. doi: 10.1073/pnas.2108006118
- Howard RJ. Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models. Journal of Molecular Biology (2021) 433(17): 167128. doi: 10.1016/j.jmb.2021.167128
- Rovšnik U, Zhuang Y, Forsberg BO, Carroni M, Yvonnesdotter L, Howard RJ, Lindahl E. Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations. Life Science Alliance (2021) 4(8): e202101011. doi: 10.26508/lsa.202101011
- Sridhar A*, Lummis SCR*, Pasini D, Mehregan A, Brams M, Kambara K, Bertrand D, Lindahl E, Howard RJ, Ulens C. Regulation of a pentameric ligand-gated ion channel by a semi-conserved cationic-lipid binding site. Journal of Biological Chemistry (2021) 297(2): 100899. doi: 10.1016/j.jbc.2021.100899
- Hu H, Howard RJ, Bastolla U, Lindahl E, Delarue M. Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the USA (2020) 117(24): 13437–13446. doi: 10.1073/pnas.1922701117
- Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature (2020) 585: 303–308. doi: 10.1038/s41586-020-2654-5
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