Rebecca (Reba) J Howard, PhD
Researcher in Biochemistry
Laboratory Manager
Department of Biochemistry & Biophysics
Stockholm University
Email: rebecca.howard@scilifelab.se
CV: rebahoward.net
Projects
Selected Publications
- Hu H, Howard RJ, Bastolla U, Lindahl E, Delarue M. Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the USA (2020) 117(24): 13437–13446. doi: 10.1073/pnas.1922701117
- Heusser SA, Lycksell M, Wang X, McComas SE, Howard RJ, Lindahl E. Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity. Proceedings of the National Academy of Sciences of the USA (2018) 115(42): 10672–10677. doi: 10.1073/pnas.1809650115
- Fourati Z*, Howard RJ*, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M. Structural basis for a bimodal allosteric mechanism of general anesthetic modulation in pentameric ligand-gated ion channels. Cell Reports (2018) 23: 993–1004. doi: 10.1016/j.celrep.2018.03.108 *equal contributions
- Howard RJ, Carnevale V, Delemotte L, Hellmich UA, Rothberg BS. Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport. Biochimica et Biophysica Acta – Biomembranes (2018) 1860: 927–942. doi: 10.1016/j.bbamem.2017.12.013
- Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ. Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel. Journal of Neurochemistry (2016) 138(2): 243–253. doi: 10.1111/jnc.13644
- Howard RJ, Trudell JR, Harris RA. Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and anesthetics. Pharmacological Reviews (2014) 66(2): 396–412. doi: 10.1124/pr.113.007468
- Howard RJ. Too much of a good thing: Evolving our relationship with alcohol . TedX Skidmore College (2014).
Profiles
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