Reba Howard

Rebecca (Reba) J Howard, PhD
Senior Researcher in Biochemistry

Stockholm University
Department of Biochemistry & Biophysics

KTH Royal Institute of Technology
Department of Applied Physics

SciLIfeLab Cellular & Molecular Imaging
Platform Coordination Officer

Email: rebecca.howard@scilifelab.se

CV: rebahoward.net

Team: Integrative Structural Biology

Selected Publications

Cowgill J*, Fan C*, Haloi N, Tobiasson V, Zhuang Y, Howard RJ°, Lindahl E°. Structure and dynamics of differential ligand binding in the human ρ-type GABA(A) receptor (2023) Neuron doi: 10.1016/j.neuron.2023.08.006
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E°, Hibbs RE°. Structural insights into opposing actions of neurosteroids on GABA(A) receptors (2023) Nature Communications 14: 5091, 2023. doi: 10.1038/s41467-023-40800-1
Yvonnesdotter L, Rovšnik U, Blau C, Lycksell M, Howard RJ, Lindahl E. Automated simulation-based membrane-protein refinement into cryo-EM data (2023) Biophysical Journal 122(13) P2773–2781. doi: 10.1016/j.bpj.2023.05.033
Choudhury K, Howard RJ, Delemotte L. An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb (2023) Journal of General Physiology 155(2): e202213214. doi: 10.1085/jgp.202213214
Lycksell M*, Rovšnik U*, Hanke A, Martel A, Howard RJ, Lindahl E. Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel (2022) Proceedings of the National Academy of Sciences of the USA 119(50): e2210669119. doi: 10.1073/pnas.2210669119
Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E. Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators (2022) Proceedings of the National Academy of Sciences of the USA 119(43): e2208081119. doi: 10.1073/pnas.2208081119
Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE. Structural and dynamic mechanisms of GABA(A) receptor modulators with opposing activities (2022) Nature Communications 13: 4582. doi: 10.1038/s41467-022-32212-4
Bergh C, Heusser SA, Howard RJ, Lindahl E. Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel (2021) eLife 10: e68369. doi: 10.7554/eLife.68369
Howard RJ. Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models. Journal of Molecular Biology (2021) 433(17): 167128. doi: 10.1016/j.jmb.2021.167128
Carnevale V*°, Delemotte L*°, Howard RJ*°. Molecular dynamics simulations of ion channels (2021)
Trends in Biochemical Sciences 46(7): 621–622. doi: 10.1016/j.tibs.2021.04.005
Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ. Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel (2016) Journal of Neurochemistry 138(2): 243–253. doi: 10.1111/jnc.13644
Howard RJ. Too much of a good thing: Evolving our relationship with alcohol (2014) TedX Skidmore College.

* Equal contributions
° Co-corresponding authors

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