In addition to the formal positions listed below, we are always interested in hearing from motivated applicants at email@example.com.
- Postdoctoral Researcher in Mass Spectrometry of Membrane Proteins
- Doctoral Student in Simulation of Assembly of Biomolecules Using pH and Flow
- Master’s/Bachelor’s Students in Laboratory & Computational Biophysics of Ion Channels
Visit the Projects page to learn more about our work and appropriate contacts.
Postdoctoral Researcher in
Mass Spectrometry of Membrane Proteins
We seek a postdoctoral researcher to investigate interactions between membrane proteins and lipids using mass spectrometry, in particular to identify lipid binding sites and understand how various lipid types modulate the function of channels and transporters. We particularly seek candidates with prior experience of structural and functional studies of membrane protein and/or mass spectrometry.
For more information about the position, please contact Professors Erik Lindahl, David Drew, or Michael Landreh. Qualification requirements, assessment criteria, terms of employment, and application materials can be found through the Stockholm University recruitment system:
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Doctoral Student in
Simulation of Assembly of Biomolecules Using pH and Flow
Bio-based materials are a promising class of materials because of their sustainability and abundance of supply, such as trees and waste products. But to get attractive material properties, such as tensile strength, the molecules involved need to be assembled in a controlled fashion into ordered structures such as fibers. Both in nature and in industry this often involves changes in pH driven by changes in solvent composition, which changes the charge of surface groups thereby significantly modifying the interactions between molecules. For industrial processing, this can be combined with flow to obtain orientation and alignment of molecules. In the flow the pH is then changed to initiate aggregation of molecules into fibers. As it is not possible to measure protonation states of surface groups in flow experimentally, the optimization of these processes is currently mostly trial and error with varying success.
In this project we will use large-scale classical molecular dynamics simulations to study aggregation of bio-molecules in flow. A newly developed dynamic protonation algorithm, which we implemented in the popular molecular simulation package GROMACS, provides the correct average protonation for groups depending on their local environment. This enables both fundamental understanding of the processes, as well as as a route to rationally optimize pH and flow conditions.
This position as a PhD student is linked with INTERFACE, a research environment funded by the Swedish Research Council using multiscale methods to study boiling, friction and synthesis of biomaterials. The INTERFACE environment is a collaboration between several groups at the departments of Applied Physics and Mechanics and the Wallenberg wood science center at KTH. The environment is multi-disciplinary, international and includes main developers of the popular GROMACS molecular simulation package, which will be used in this project.
The doctoral student will be placed at the KTH Royal Institute of Technology and supervised by Professor Berk Hess. Benefits, eligibility, application and selection materials can be found through the KTH recruitment system:
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Master’s/Bachelor’s Student Research Positions in
Laboratory & Computational Biophysics of Ion Channels
Three types of Research/Degree Projects are currently available in the ligand-gated ion channels team, headed by Professor Erik Lindahl. Under the supervision of Dr. Reba Howard, students will focus on laboratory or computational biophysics approaches to investigate the structure and function of proteins involved in cellular regulation and signaling, particularly the activation and modulation of ion channels.
Project 1—Electrophysiology of Novel Receptor Variants
Express and characterize ion channel proteins in Xenopus oocytes, using molecular biology and voltage-clamp recordings to quantify expression, gating, and modulation towards structure determination and drug development.
Project 2—Simulating Ion Channel Gating and Modulation
Harness recent structure-function data to simulate and analyze ion channel models, using methods such as molecular dynamics and docking to probe structural changes, drug binding, and novel mutations.
Project 3—Methods Development in Cryo-Electron Microscopy
Optimize sample preparation, data collection, and/or image analysis to elucidate the atomic structure of technically challenging macromolecules, focusing on biochemistry or software methods in cryo-electron microscopy.
Applicants should have some theoretical and/or laboratory preparation in biophysics, biochemistry, or related fields at the Bachelor’s or Master’s levels, and an enthusiasm for interdisciplinary research and communication. Contact firstname.lastname@example.org for further details.