Department of Biochemistry & Biophysics
Projects: Ligand-gated ion channels
Stephanie completed her PhD in Biochemistry in May 2018 but remains as a postdoctoral scholar in this group for the summer months of 2018. Stephanie’s research focuses on the exploration of the molecular interactions between general anesthetics and ligand-gated ion channels. She mainly uses voltage-clamp electrophysiology along with other biochemical experimental techniques to explore the mechanisms of allosteric modulation and channel activation.
- 2014-2018: PhD student in Biochemistry, Stockholm University, Sweden
- 2013-2014: Pharmacist Eidg. Dipl. ETH, Adler Apotheke Winterthur, Switzerland
- 2008-2013: M.Sc.and B.Sc. in Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH, Zürich, Switzerland
Fourati Z.*, Howard R.J.*, Heusser S.A., Sauguet L., Hu H., Ruza R.R., Lindahl E., and Delarue M. (2018)Structural basis for bimodal allosteric mechanism of general anesthetic modulation in pentameric ligand-gated ion channels, Cell reports 23, 993-1004.
Heusser S.A., Yoluk O., Klement G., Riederer E.A., Lindahl E., and Howard R.J. (2016) Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel, Journal of Neurochemistry 138, 243-253
Heusser S.A., Howard R.J., Borghese C.M., Cullins M.A., Broemstrup T., Lee U.S., Lindahl E., Carlsson J., and Harris R.A. (2013) Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels, Molecular Pharmacology 84, 670-678.