Reba Howard

Rebecca (Reba) J Howard, PhD

Senior Researcher in Biochemistry
Stockholm University
Department of Biochemistry & Biophysics

Platform Coordination Officer
KTH Royal Institute of Technology
Department of Applied Physics

Email: rebecca.howard@scilifelab.se

CV: rebahoward.net

Team: Integrative Structural Biology

Selected Publications

Fan C*, Cowgill J*, Howard RJ°, Lindahl E°. Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor (2024) Nature Communications 15(1): 7795. doi: 10.1038/s41467-024-51904-7
Cowgill J*, Fan C*, Haloi N, Tobiasson V, Zhuang Y, Howard RJ°, Lindahl E°. Structure and dynamics of differential ligand binding in the human ρ-type GABA(A) receptor (2023) Neuron 11(21): p3450-3464.e5. doi: 10.1016/j.neuron.2023.08.006
Lycksell M*, Rovšnik U*, Hanke A, Martel A, Howard RJ, Lindahl E. Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel (2022) Proceedings of the National Academy of Sciences of the USA 119(50): e2210669119. doi: 10.1073/pnas.2210669119
Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E. Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators (2022) Proceedings of the National Academy of Sciences of the USA 119(43): e2208081119. doi: 10.1073/pnas.2208081119
Howard RJ. Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models. Journal of Molecular Biology (2021) 433(17): 167128. doi: 10.1016/j.jmb.2021.167128
Carnevale V*°, Delemotte L*°, Howard RJ*°. Molecular dynamics simulations of ion channels (2021)
Trends in Biochemical Sciences 46(7): 621–622. doi: 10.1016/j.tibs.2021.04.005
Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ. Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel (2016) Journal of Neurochemistry 138(2): 243–253. doi: 10.1111/jnc.13644
Howard RJ. Too much of a good thing: Evolving our relationship with alcohol (2014) TedX Skidmore College.

* Equal contributions
° Co-corresponding authors

Profiles