Lucie Delemotte

Assistant Professor of Biophysics
Department of Applied Physics
KTH Royal Institute of Technology



Lucie graduated from the Université de Lorraine in France in 2011, where she did her PhD under the supervision of Mounir Tarek. She was a post doc and a Marie Curie fellow in the group of Mike Klein at Temple University in the USA and in the group of Ursula Roethlisberger at EPFL in Switzerland. Her main research focus is on mechanisms of membrane transport and of allosteric regulation and the development of protocols that enable to describe these phenomena in a quantitative manner.

Projects: Membrane-Protein Modeling

Group Members




Recent Selected Publications

Full list at: Google Scholar


Molecular basis for voltage sensitivity in membrane proteins MA Kasimova, E Lindahl and L Delemotte, BioRXiv, DOI: 1

Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker Kchannel AI Fernández-Mariño, TJ Harpole, K Oelstrom, L Delemotte and B Chanda, Nat. Struct. Mol. Biol. DOI: 10.1038/s41594-018-0047-3

Effect of Ca2+ on the promiscuous target-protein binding mechanism of calmodulin A Westerlund, L Delemotte, PloS Comp Biol, DOI: 10.1371/journal.pcbi.1006072

Exploring the Viral Channel KcvPBCV‑1 Function via Computation AEV Andersson, MA Kasimova, L Delemotte, J. Memb. Biol. DOI: 10.1007/s00232-018-0022-2


Inference of Calmodulin’s Ca2+-Dependent Free Energy Landscapes via Gaussian Mixture Model Validation AM Westerlund, TJ Harpole, C Blau and L Delemotte, J. Chem. Theor. Comp. DOI: 10.1021/acs.jctc.7b00346

Conformational landscapes of membrane proteins delineated by enhanced sampling molecular dynamics simulations TJ Harpole, L Delemotte, BBA Biomem. DOI: 10.1016/j.bbamem.2017.10.033


Does proton conduction in the voltage-gated H+ channel hHv1 involve grotthuss-like hopping via acidic residues? S C van Keulen, E Gianti, V Carnevale, ML Klein, U Rothlisberger and L Delemotte, J. Phys. Chem. B, DOI: 10.1021/acs.jpcb.6b08339


Characterization of the honeybee AmNav1 channel and tools to assess the toxicity of insecticides P Gosselin-Badaroudine, A Moreau, L Delemotte, T Cens, C Collet, … Scientific reports 5

Comparative sequence analysis suggests a conserved gating mechanism for TRP channels E Palovcak, L Delemotte, ML Klein, V Carnevale The Journal of general physiology 146 (1), 37-50

Free-energy landscape of ion-channel voltage-sensor–domain activation L Delemotte, MA Kasimova, ML Klein, M Tarek, V Carnevale Proceedings of the National Academy of Sciences 112 (1), 124-129