Skin Drug Delivery

Using cryo-electron microscopy data as a reference, molecular dynamics simulations have been used to model the formation process of human skin, and to study the final barrier structure. This model of the main barrier of human skin is used to calculate the permeability of active pharmaceutical ingredients and to study the effects of excipients in dermal/transdermal formulations, regarding penetration modifying effects as well as how they actually function.

Contributors

Featured publications

Lundborg, M.; Wennberg, C. L.; Narangifard, A.; Lindahl, E.; Norlén, L. Predicting drug permeability through skin using molecular dynamics simulation. J. Contr. Rel. 2018, 283, 269-279.
Lundborg, M.; Narangifard, A.; Wennberg, C. L.; Lindahl, E.; Daneholt, B.; Norlén, L. Human skin barrier structure and function analyzed by cryo-EM and molecular dynamics simulation. J. Struct. Biol. 2018, 366 (2), 139-151.
Narangifard, A.; den Hollander, L.; Wennberg, C. L.; Lundborg, M.; Lindahl, E.; Iwai, I.; Han, H.; Masich, S.; Daneholt, B.; Norlén, L. Human skin barrier formation takes place via a cubic to lamellar lipid phase transition as analyzed by cryo-electron microscopy and EM-simulation. Exp. Cell Res. 2018, 366, 139-151.
Wennberg, C. L.: Narangifard, A.; Lundborg, M.; Norlén, L.; Lindahl, E. Structural transitions in ceramide cubic phases during formation of the human skin barrier. Biophys J. 2018, 114, 1116-1127.