Postdoctoral Fellow
Department of Applied Physics
KTH Royal Institute of Technology
Team: Membrane Protein Modeling
Email: adrien.schahl@scilifelab.se
Biography:
Adrien Schahl graduated from the University of Toulouse in 2020, where he did his Ph.D. under the supervision of Franck Jolibois and Valérie Réat. During his Ph.D he studied interactions between polysaccharides and lipids that may be found at the surface of Mycobacterium tuberculosis, using quantum chemical calculations, molecular dynamics simulations and solid-state NMR experiments.
He then became a postdoc in the groups of Matthieu Chavent from the IPBS-Toulouse and Jean-Philip Piquemal from Sorbonne University, from 2021 to 2023. There, he studied the Actin protein under monomeric and filamentous forms, using multi-scale molecular dynamics simulations, and enhanced sampling methods.
Finally he joined the group of Lucie Delemotte, in Molecular biophysics Stockholm at SciLifelab, starting in September 2023. His main interest resides now in the study of membrane proteins involved in cellular signalling, using multi-scale molecular dynamics simulations, and enhanced sampling methods.
Publications:
Actin Modeling:
- Adrien Schahl, Louis Lagardère, Brandon Walker, Pengyu Ren, Antoine Jégou, Matthieu Chavent, Jean-Philip Piquemal. B-Actin plasticity is modulated by coordinated action of histidine 73 methylation, nucleotide type and ions. biorXiv, 2022.
Soluble Proteins:
- Dusan Zivkovic, Angelique Sanchez Dafun, Thomas Menneteau, Adrien Schahl, Sandrine Lise, Christine Kervarrec, Ana Toste Rego, Paula Da Fonseca, Matthieu Chavent, Charles Pineau, Odile Burlet-Schiltz, Julien Marcoux, Marie-Pierre Bousquet. Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis. PNAS, 2022, 119(15).
Polysaccharides-lipids:
- Adrien Schahl, Anne Lemassu, Franck Jolibois, Valérie Réat. Evidence for amylose inclusion complexes with multiple acyl chain lipids using solid-state NMR and theoretical approaches. Carbohydrate Polymers, 2022, 276.
- Adrien Schahl, Iann Gerber, Valérie Réat, Franck Jolibois. Diversity of hydrogen bond network and its impact on NMR parameters of amylose B polymorph. A study using molecular dynamics and DFT calculations within periodic boundary conditions. Journal of Physical Chemistry B, 2021,125(1):158-168.
- Adrien Schahl, Valérie Réat, Franck Jolibois. Structures and NMR spectra of short amylose-lipid complexes. Insight using molecular dynamics and DFT quantum chemical calculations. Carbohydrate Polymers, 2020, 235.
External links:
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