Review of the Skin Barrier Formation

Published online August 31, 2021 in Journal of Investigative Dermatology (doi

The Skin’s Barrier: A Cryo-EM Based Overview of its Architecture and Stepwise Formation

Lars Norlén, Magnus Lundborg, Christian Wennberg, Ali Narangifard, Bertil Daneholt

A major role of the skin is to serve as a barrier toward the environment. The skin’s permeability barrier consists of a lipid structure positioned in the stratum corneum. Recent progress in high-resolution cryo-electron microscopy (cryo-EM) has allowed for elucidation of the architecture of the skin’s barrier and its stepwise formation process representing the final stage of epidermal differentiation. In this review, we present an overview of the skin’s barrier structure and its formation process, as evidenced by cryo-EM.

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