Skin Structure and Formation

Using cryo-electron microscopy data as a reference, molecular dynamics simulations are utilized in order to model the formation process of human skin, and to study the final barrier structure. Additionally, there is a close collaboration with industry in order to test the predictive properties of molecular dynamics simulations applied to transdermal drug delivery.

Contributors

Featured publications

Lundborg, M.; Wennberg, C. L.; Narangifard, A.; Lindahl, E.; Norlén, L. Predicting drug permeability through skin using molecular dynamics simulation. J. Contr. Rel. 2018, 283, 269-279.
Lundborg, M.; Narangifard, A.; Wennberg, C. L.; Lindahl, E.; Daneholt, B.; Norlén, L. Human skin barrier structure and function analyzed by cryo-EM and molecular dynamics simulation. J. Struct. Biol. 2018, 366 (2), 139-151.
Narangifard, A.; den Hollander, L.; Wennberg, C. L.; Lundborg, M.; Lindahl, E.; Iwai, I.; Han, H.; Masich, S.; Daneholt, B.; Norlén, L. Human skin barrier formation takes place via a cubic to lamellar lipid phase transition as analyzed by cryo-electron microscopy and EM-simulation. Exp. Cell Res. 2018, 366, 139-151.
Wennberg, C. L.: Narangifard, A.; Lundborg, M.; Norlén, L.; Lindahl, E. Structural transitions in ceramide cubic phases during formation of the human skin barrier. Biophys J. 2018, 114, 1116-1127.