Department of Applied Physics
KTH Royal Institute of Technology
Email: marina.kasimova at scilifelab.se
- Membrane Protein Modeling – Molecular Mechanisms of Ion Channels’ Gating
Marina was born in Elektrostal (Russia), a small town close to Moscow. She did her bachelor and master studies at Moscow State University at the Department of Biology. After graduation, she started her PhD with Mounir Tarek at the University of Lorraine in France. During the 3 years of her PhD, Marina was exploring the modulation of voltage-gated potassium channels (Kv) by membrane lipids. When she finished her PhD, Marina moved to Phliadelphia, USA, to do postdoctoral studies under the supervision of Michael Klein and Vincenzo Carnevale (2 years). She was mostly focusing on TRP channels, exploring their mechanism of gating and temperature sensitivity. After this postdoc, Marina started to work at the Science for Life Laboratory with Lucie Delemotte, Erik Lindahl and Berk Hess. Here, she develops a protocol to detect voltage-sensing elements in membrane proteins. She also explores the gating of hyperpolarization-activated cyclic-nucleotide-gated ion channels using resources of Anton supercomputer. In her free time, Marina likes doing fitness, listening scientific podcasts and reading.
List of Publications:
A.E. Andersson, M.A. Kasimova, L. Delemotte, Exploring the viral channel KcvPBCV-1 function via computation, J Membr Biol. 2018. just accepted.
X. Steinberg*, M.A. Kasimova*, D. Cabezas-Bratesco, J.D. Galpin, E. Ladron-de-Guevara, F. Villa, V. Carnevalle, L. Islas, C.A. Ahern, S. Brauchi, Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid, eLife. 2017. 6: e28626.
M.A. Kasimova, D. Granata, V. Carnevale, Voltage-gated sodium channels: evolutionary history and distinctive sequence features, Current Topics in Membranes. 2016. 78:261-86.
P. Velisetty, I. Borbiro, M.A. Kasimova, L. Liu, V. Carnevale, T. Rohacs, A molecular determinant of phosphoinositide affinity in mammalian TRPV channels, Sci Rep. 2016. 6: 27652.
M. Casciola, M.A. Kasimova, L. Rems, S. Zullino, F. Apollonio, M. Tarek, Properties of lipid electropores I: Molecular dynamics simulations of stabilized pores by constant charge imbalance, Bioelectrochemistry. 2016. 109:108-116.
Z. Cournia, T.W. Allen, I. Andricioaei, B. Antonny, D. Baum, G. Brannigan, N.V. Buchete, J.T. Deckman, L. Delemotte, C. Del Val, R. Friedman, P. Gkeka, H.C. Hege, J. Henin, M.A. Kasimova, A. Kolocouris, M.L. Klein, S. Khalid, M.J. Lemieux, N. Lindow, M. Roy, J. Selent, M. Tarek, F. Tofoleanu, S. Vanni, S. Urban, D.J. Wales, J.C. Smith, A.N. Bondar, Membrane protein structure, function, and dynamics: a perspective from experiments and theory, J Membr Biol. 2015. 248(4): 611-60.
M.A. Kasimova, M.A. Zaydman, J. Cui, M. Tarek, PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6, Sci Rep. 2015. 5: 7474.
L. Delemotte, M.A. Kasimova, M.L. Klein, M. Tarek, V. Carnevale, Free energy landscape of ion-channel voltage-sensor-domain activation, PNAS. 2015. 112(1): 124-9.
M.A. Zaydman, M.A. Kasimova, K. McFarland, H. Liang, Z. Beller, J. Shi, M. Tarek, J. Cui, Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel, eLife. 2014. 3: e03606.
M.-Y. Amarouch, M.A. Kasimova, M. Tarek, H. Abriel, Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies, Channels (Austin). 2014. 8(5): 414-20.
Grizel, A. Popinako, M.A. Kasimova, L. Stevens, M. Karlova, M.M. Moisenovich, O. Sokolova, Domain structure and conformational changes in rat Kv2.1 ion channel, J Neuroimmune Pharmacol. 2014. 9(5): 727-39.
M.A. Kasimova, M. Tarek, A.K. Shaytan, K.V. Shaitan, L. Delemotte, Voltage-gated ion channels modulation by lipids: insights from molecular dynamics simulations, BBA biomembranes. 2014. 1838(5): 1322-31.
F. Abderemane-Ali, Z. Es-Salah-Lamoureux, L. Delemotte, M.A. Kasimova, A.J. Labro, D.J. Snyders, D. Fedida, M. Tarek, I. Baró, G. Loussouarn, Dual regulation of Shaker K+ channels by phosphatidylinositol-(4,5)-bisphosphate, JBC. 2012. 287: 36158-67.
* These authors contributed equally.